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Best Nicotine Replacement Therapies of 2023

April 25, 2025
10 min read
HomeBlogBest Nicotine Replacement Therapies of 2023
Best Nicotine Replacement Therapies of 2023

Our medical team reviews the latest NRT products to help you find the most effective option for your needs.

Dr. Sarah Johnson

Written by Dr. Sarah Johnson

Addiction Specialist

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Understanding Nicotine Replacement Therapy

Nicotine replacement therapy (NRT) works by providing controlled amounts of nicotine without the harmful chemicals found in cigarettes. This approach helps reduce withdrawal symptoms and cravings while you break the behavioral habits associated with smoking.

Research consistently shows that using NRT can increase your chances of quitting successfully by 50-60% compared to quitting without support. When used correctly, these products are safe and effective for most adults.

Types of Nicotine Replacement Products

There are several FDA-approved NRT options available, each with unique advantages and considerations:

Nicotine Patches

How they work: Patches deliver a steady dose of nicotine through the skin over 16-24 hours.

Best for: Providing consistent nicotine levels to manage background cravings. Particularly helpful for heavy smokers and those who need nicotine throughout the day.

Top products for 2023:

  • NicoDerm CQ: Available in three strengths (21mg, 14mg, 7mg) for a step-down approach. The clear design makes it nearly invisible on skin.
  • Habitrol: Offers comparable efficacy to NicoDerm at a lower price point.
  • Equate (Walmart): Budget-friendly option that delivers reliable performance.

Usage tips: Apply to a clean, dry, hairless area of skin. Rotate application sites daily to prevent skin irritation. If you experience vivid dreams or sleep disturbances, remove the patch before bedtime.

Nicotine Gum

How it works: Releases nicotine when chewed, which is absorbed through the lining of the mouth.

Best for: Managing sudden cravings and providing oral stimulation. Good for situational smokers who need on-demand relief.

Top products for 2023:

  • Nicorette: Available in 2mg and 4mg strengths with the widest variety of flavors. The coated version reduces the initial bitter taste.
  • CVS Health: Comparable to Nicorette with a more affordable price tag.
  • Lucy Gum: Newer entrant with modern packaging and a variety of flavors designed to appeal to younger users.

Usage tips: Use the "chew and park" method—chew until you notice a tingling sensation, then "park" the gum between your cheek and gums until the sensation fades. Avoid eating or drinking (except water) for 15 minutes before and during use.

Nicotine Lozenges

How they work: Dissolve slowly in the mouth, releasing nicotine that is absorbed through the lining of the mouth.

Best for: Those who prefer not to chew gum or want a more discreet option. Provides similar benefits to gum with less jaw fatigue.

Top products for 2023:

  • Nicorette Mini Lozenges: Smaller size dissolves faster and delivers nicotine more quickly than standard lozenges.
  • Equate: Cost-effective option that performs well in user satisfaction surveys.
  • Thrive: Pharmaceutical-grade lozenges with a clean ingredient list and minimal additives.

Usage tips: Allow to dissolve completely without chewing or swallowing. Move the lozenge around in your mouth occasionally. As with gum, avoid eating or drinking for 15 minutes before and during use.

Nicotine Inhalers

How they work: Consist of a plastic mouthpiece and nicotine cartridge. When you puff, nicotine vapor is released and absorbed primarily through the mouth and throat.

Best for: Those who miss the hand-to-mouth action of smoking. Provides both behavioral and physical aspects of smoking.

Top products for 2023:

  • Nicorette Inhaler: The only FDA-approved nicotine inhaler in the U.S. market. Each cartridge provides about 20 minutes of active use.

Usage tips: Puff frequently for best results. Each cartridge can last for about 20 minutes of active "puffing." Use in temperatures above 50°F for optimal nicotine delivery.

Nicotine Nasal Spray

How it works: Delivers nicotine directly to the nasal lining, providing the fastest relief of any NRT product.

Best for: Heavy smokers who need rapid relief from intense cravings.

Top products for 2023:

  • Nicotrol NS: The only FDA-approved nicotine nasal spray. Available by prescription only.

Usage tips: Tilt your head back slightly when spraying. Initial nasal irritation is common but typically subsides within a week. Avoid sniffing, swallowing, or inhaling through the nose while spraying.

Combination Approaches

Research shows that combining different forms of NRT can be more effective than using a single product. The most common and effective combination is:

  • Long-acting NRT (patch) to provide steady background nicotine levels
  • Plus a rapid-acting form (gum, lozenge, inhaler, or spray) to manage breakthrough cravings

This approach addresses both the constant need for nicotine and the sudden cravings that can trigger relapse.

Choosing the Right NRT for You

Consider these factors when selecting a nicotine replacement product:

  • Smoking patterns: Heavy smokers (more than 20 cigarettes daily) typically need higher-strength products.
  • Personal preferences: If you enjoy the oral satisfaction of smoking, gum or lozenges might work better. If you miss the hand-to-mouth ritual, an inhaler could be more satisfying.
  • Previous quit attempts: If you've tried one form of NRT without success, consider a different product or combination approach.
  • Lifestyle factors: Consider discretion needs, work environment, and daily routine when choosing a product.

Using NRT Effectively

To maximize your chances of success with nicotine replacement therapy:

  • Start on your quit date: Begin using NRT the day you stop smoking, not before.
  • Use the correct dosage: Underdosing is a common mistake. Start with a higher dose if you're a heavy smoker.
  • Follow the full treatment course: Most NRT products should be used for 8-12 weeks, with gradual reduction in dosage.
  • Combine with behavioral support: NRT works best when paired with counseling or support groups.
  • Be patient with side effects: Minor side effects often resolve within a few days as your body adjusts.

Special Considerations

While NRT is safe for most adults, consult your healthcare provider before using if you:

  • Are pregnant or breastfeeding
  • Have had a recent heart attack or have severe arrhythmia
  • Have uncontrolled high blood pressure
  • Have severe temporomandibular joint (TMJ) disease (for gum)
  • Have significant nasal or sinus conditions (for nasal spray)
  • Take insulin for diabetes (nicotine can affect insulin requirements)

Remember that while NRT can significantly increase your chances of quitting successfully, it's just one tool in the quitting process. Combining NRT with behavioral strategies and support provides the best chance of becoming smoke-free for good.

About the Author

Dr. Sarah Johnson

Dr. Sarah Johnson

Addiction Specialist

Dr. Sarah Johnson is a addiction specialist with expertise in smoking cessation and addiction treatment. They have helped thousands of people successfully quit smoking and live healthier lives.

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